Enurex 200 Tablet

✔️ Uses | Enurex 200

Enurex 200 Tablet is used to treat diabetes insipidus, a condition that causes excessive urination and intense thirst. It is also used to manage excessive urination and thirst after pituitary surgery (post-hypophysectomy polyuria and polydipsia).

✔️ Drug Interactions

Although the pressor (blood pressure–raising) effect of Enurex is minimal compared to its antidiuretic action, high doses should be used cautiously when combined with other pressor agents, with close patient monitoring.
Concomitant use with medications that increase the risk of water retention and hyponatremia—such as tricyclic antidepressants, SSRIs, chlorpromazine, opioid analgesics, NSAIDs, lamotrigine, and carbamazepine—should be undertaken with caution.

✔️ Dosage & Administration | Enurex 200

Sublingual Tablet

Diabetes Insipidus:
Dosage is individualized based on patient response. The usual total daily sublingual dose ranges from 120 micrograms to 720 micrograms.
A typical starting dose for both adults and children is 60 micrograms taken sublingually three times daily. The dose should then be adjusted according to clinical response. For most patients, the maintenance dose is 60–120 micrograms sublingually three times daily.

Post-hypophysectomy Polyuria/Polydipsia:
The dose of desmopressin acetate melt should be adjusted based on urine osmolality measurements.

Film-Coated Tablet

Adults and Children:
Treatment should begin with 0.05 mg (half of a 0.1 mg tablet) twice daily, followed by gradual dose adjustment to achieve optimal therapeutic response.
Most patients respond well to a total daily dose between 0.1 mg and 0.8 mg, administered in divided doses. Each dose should be tailored to maintain an appropriate day–night balance of water regulation.
If needed, the total daily dose may be adjusted within the range of 0.1 mg to 1.2 mg, given in two or three divided doses to ensure adequate antidiuretic effect.

Geriatric Use

Desmopressin is primarily eliminated through the kidneys. Since elderly patients are more likely to have reduced renal function, careful dose selection is required. Monitoring renal function may be advisable to minimize the risk of adverse effects.

✔️ Side Effects

Occasionally, high doses—particularly of intranasal or injectable formulations—have caused temporary symptoms such as headache, nausea, flushing, and mild abdominal cramps. These effects typically resolve after dose reduction.

✔️ Precautions & Warnings

Rare cases of hyponatremia have been reported in post-marketing surveillance. As desmopressin is a potent antidiuretic, improper use may lead to water intoxication, which can be life-threatening if not promptly treated. Fluid restriction is essential and should be clearly explained to the patient or caregiver. Continuous medical monitoring is strongly recommended.

High-dose intranasal formulations and injectable desmopressin have occasionally caused mild, reversible increases in blood pressure. Although this effect has not been observed with single oral doses up to 0.6 mg, caution is advised in patients with coronary artery disease or hypertension.

✔️ Storage:

Store in a cool and dry place, away from sunlight

Keep out of reach of children

Store between 10°C and 25°C, or below 30°C

Does not require cold-chain storage